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baclofen overdose

see also:


  • baclofen is a synthetic derivative of GABA and in Rx doses, mainly acts upon GABA-B receptors, inhibiting the release of the excitatory amino acids glutamate and aspartate
  • in overdoses > 200mg in adults, this can result in significant CNS depression causing sedation and coma which may be profound and prolonged with hyporeflexia, hypotonia, fixed, dilated pupils, lasting 24-48hrs and thus admission to a ICU/HDU is generally needed
  • it may also cause:
    • resp. depression
    • sinus bradycardia
    • sinus tachycardia
    • hypertension
    • 1st degree heart block

Mx of overdose

  • most overdoses are minor and if asymptomatic or ingestion < 200mg in adults, can usually be discharged within 4hrs following ingestion
  • in severe overdoses, Mx is supportive care
  • following recovery from overdose one should recommence usual baclofen doses to prevent withdrawal syndrome (see below)

baclofen withdrawal syndrome

  • may occur 24-48hrs after cessation of baclofen
  • hallucinations
  • visual disturbances
  • seizures
  • dyskinesia
odbaclofen.txt · Last modified: 2015/09/25 10:42 (external edit)