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odchloralhydrate

chloral hydrate overdose

introduction

  • chloral hydrate is a sedative hypnotic agent which acts via GABA receptors and is metabolised by RBC's to trichloroethanol within ~4 minutes, and then hours later is metabolised further to trichloroacetic acid.
  • overdoses > 3-10g in an adult can be fatal via a variety of mechanisms including:
    • cardiotoxicity - VT/VF (avoid use of sympathomimetics to maintain BP)
    • hypotension
    • GIT erosive effects
    • hepatotoxicity
    • nephrotoxicity
    • CNS depression, especially when combined with other CNS depressants such as alcohol, barbiturates
  • long-term use of chloral hydrate is associated with a rapid development of tolerance to its effects and possible addiction as well as adverse effects including rashes, gastric discomfort and severe renal, cardiac and hepatic failure.
odchloralhydrate.txt · Last modified: 2011/08/14 15:01 (external edit)