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rifampicin

rifampicin

see also:

introduction

  • rifampicin is a rifamycin antibiotic which inhibits DNA dependent RNA polymerase activity in susceptible cells
  • it is mainly used for:
  • particularly active against rapidly growing extracellular organisms
  • has bactericidal activity intracellularly and against slow and intermittently growing Mycobacterium tuberculosis

C/I

  • jaundice
  • HS to rifamycin
  • concurrently with the combination of saquinavir/ ritonavir
  • PH rifampicin induced thrombocytopenia, purpura, haemolytic anaemia or renal failure

precautions

  • may cause or increase risk of drug-induced hepatitis, eg when used with isoniazid
  • competes with bilirubin for excretory pathways in liver cells thuis may cause jaundice during start of Rx
  • resistance may rapidly occur
  • rifampicin syrup contains sodium metabisulfite which may cause allergic reactions is some people
  • urine, faeces, saliva, sputum, sweat and tears may be coloured red-orange - avoid in patients with soft contact lenses which may become permantly stained
  • has enzyme induction properties that can enhance the metabolism of endogenous substrates
  • may exacerbate porphyrias
  • category C in pregnancy
    • bleeding attributable to hypoprothrombinaemia has been reported in newborn infants and in mothers after the use of rifampicin during late pregnancy. If rifampicin is used during the last few weeks of pregnancy, vitamin K should be given to the mother and the newborn infant.
  • avoid in lactation as passes into breast milk
  • avoid in newborn infants as liver enzymes not adequately developed

drug interactions

adverse effects

dose

  • once daily oral doses 30min before or 2hrs after food

pulmonary TB or prophylaxis of meningitis in contacts

  • adults: 600mg/day for 4 days
  • children over 5yrs: 10 mg/kg/day for four days, not to exceed 600 mg/day
rifampicin.txt · Last modified: 2014/04/10 04:18 by 127.0.0.1

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