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--- endo_chemicals [2026/04/01 00:46] – [Sources of EDCs] gary1
+++ endo_chemicals [2026/07/07 23:58] (current) – [Pathophysiology] gary1
@@ Line 19: / Line 19: @@
   *may activate pregnane X receptor (PXR) (a major regulator of drug metabolism) which then increases SHBG levels and total testosterone levels(([[https://onlinelibrary.wiley.com/doi/10.1111/bcpt.70218|2026: Pregnane X Receptor Regulates Human Endocrine System by Inducing Sex Hormone–Binding Globulin Expression]]))
   *it seems exposures may reduce [[vitD]] levels and reduce sleep duration (([[https://www.mdpi.com/2072-6643/16/9/1291]]))
+  *risk of precocious puberty or early breast development increases by 44% for every twofold increase in BPA levels and triples in the case of benzophenones(([[https://link.springer.com/article/10.1007/s00431-026-06919-1|2026: Association of exposure to synthetic phenols and metal(loid)s with early puberty in Spanish girls: a multicentric case–control study]]))
 =====Sources of EDCs=====