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endo_chemicals

endocrine disrupting chemicals (EDCs)

Introduction

  • endocrine disrupting chemicals (EDCs) are chemicals which can mimic, block, or interfere with the body's hormones
  • 95% of people have endocrine disrupting chemicals in their body
  • there are over 800 chemicals recognised or suspected of being EDCs
  • xenoestrogens (XE) include as parabens and phthalates which are commonly used in personal care products (PCPs) and which may increase the risk of breast cancer 1)

Pathophysiology

  • may mimic, block, or interfere with the body's hormones
  • may activate pregnane X receptor (PXR) (a major regulator of drug metabolism) which then increases SHBG levels and total testosterone levels2)
  • it seems exposures may reduce vitamin D levels and reduce sleep duration 3)

Sources of EDCs

    • in plastic containers, especially squeezy plastic bottles
    • avoid putting food in these containers into a microwave especially fatty foods which tend to absorb chemicals
    • avoid personal care products (PCPs) containing these
  • bisphenols (Bisphenol A (BPA), etc) such as bisphenol A (BPA)
    • chemicals used in the lining of some food and beverage packaging to protect food from contamination and extend shelf life
    • in addition to its endocrine effects, during fetal development, the combination of BPA and retinoic acid (RA) appears to trigger abnormal brain and facial development by overstimulating RA-responsive genes, particularly a group known as HOX genes 4)
    • BPA is now removed from many plastics but “BPA-free” may just mean they have been substituted with inadequately researched substances - often another BPA-like one
      • concerns have been raised that some BPA substitutes may also cause adverse effects such as on the ovary5)
  • dioxins
    • can be released from plastics which are reheated and then can be absorbed into food
  • other examples:
    • oily fish like tuna, sardines, for example, they can absorb a lot of those chemicals from their environment
    • tinned food is often lined with plastics
    • herbicides and pesticides sprayed onto fruit and vegetables

Minimising your exposure

  • don't put plastic containers into the microwave
  • avoid re-using plastic bottles
  • transfer foods from plastic to china or stainless steel as soon as possible
  • minimise tinned foods with plastic seals inside
  • minimise oily fish intakes
  • wash fruit and vegetables
  • avoid handling paper receipts, especially with wet hands and don't keep them in your wallet
  • avoid personal care products (PCPs) containing these chemicals
endo_chemicals.txt · Last modified: 2026/04/01 00:46 by gary1

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