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leukaemia [2025/11/05 09:44] – [acute myelogenous leukaemia (AML)] gary1leukaemia [2025/11/05 09:49] (current) gary1
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   *[[http://en.wikipedia.org/wiki/Leukemia|wikipedia]]   *[[http://en.wikipedia.org/wiki/Leukemia|wikipedia]]
  
-=====introduction=====+=====Introduction=====
   *usually present by causing anaemia, bleeding from thrombocytopenia, or infections or mouth ulcers from impaired immunity from inadequate mature, functional white cells   *usually present by causing anaemia, bleeding from thrombocytopenia, or infections or mouth ulcers from impaired immunity from inadequate mature, functional white cells
   *chronic forms may be detected incidentally on blood films, or by finding [[hepatosplenomegaly]], or Ix of anorexia, night sweats or LOW   *chronic forms may be detected incidentally on blood films, or by finding [[hepatosplenomegaly]], or Ix of anorexia, night sweats or LOW
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     ***myeloid** or myelogenous     ***myeloid** or myelogenous
   *hence 4 main types based upon the above combinations plus some less common types   *hence 4 main types based upon the above combinations plus some less common types
 +  *it seems all leukaemias have a common histopathology of special droplets ("C-bodies") inside their nuclei which coordinate the leukaemic phenotype - interfering with these stop the leukaemia cell from dividing and they then mature into normal cells. (([[https://www.cell.com/cell/fulltext/S0092-8674(25)01149-3|2025: Disparate leukemia mutations converge on nuclear phase-separated condensates]]))
  
  
leukaemia.txt · Last modified: 2025/11/05 09:49 by gary1

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