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spinal_stenosis [2026/06/10 00:00] – [aetiology] gary1spinal_stenosis [2026/06/10 00:14] (current) gary1
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 =====Introduction===== =====Introduction=====
   *spinal stenosis is narrowing of the spinal canal or neural foraminae resulting in pressure on the spinal cord or nerve roots   *spinal stenosis is narrowing of the spinal canal or neural foraminae resulting in pressure on the spinal cord or nerve roots
 +  *"central stenosis" is used if the whole central spinal canal is compressed, and "foraminal or lateral stenosis" if the single nerve root exiting the neural foramina is compressed
   *lumbar stenosis is most common followed by cervical stenosis   *lumbar stenosis is most common followed by cervical stenosis
   *1st described by Antoine Portal in 1803   *1st described by Antoine Portal in 1803
  
  
-=====Lumbar spinal stenosis===== +=====Lumbar spinal stenosis (LSS)===== 
-====aetiology====+====Aetiology====
   *usually degenerative as a result of arthritis of the facet joints and thus occurs mainly in those over 50yrs age and females are at higher risk   *usually degenerative as a result of arthritis of the facet joints and thus occurs mainly in those over 50yrs age and females are at higher risk
     * as the disks dry out with age and lose height, more weight is taken on by the facet joints leading to arthritic changes and the neural foraminae become smaller     * as the disks dry out with age and lose height, more weight is taken on by the facet joints leading to arthritic changes and the neural foraminae become smaller
     * affects some 8% of the elderly population     * affects some 8% of the elderly population
   *congenital forms may present between ages 30 and 50 yrs   *congenital forms may present between ages 30 and 50 yrs
 +    * congenitally small central canal 
   *genetic factors   *genetic factors
 +    * heritability of LSS appears to be 0.67
     * over 88 genetic regions are associated(([[https://www.nature.com/articles/s41467-026-70935-w|2026: Genetic architecture of lumbar spinal stenosis]]))     * over 88 genetic regions are associated(([[https://www.nature.com/articles/s41467-026-70935-w|2026: Genetic architecture of lumbar spinal stenosis]]))
     * at least 32 genetic regions are associated to more advanced forms of the disease requiring surgical treatment     * at least 32 genetic regions are associated to more advanced forms of the disease requiring surgical treatment
 +    * most variants influence risk after midlife, but some confer susceptibility as early as age 34
   *other causes include [[RhA]], [[AS]], spinal tumours, trauma, Paget's disease, scoliosis, spondylolisthesis, achondroplasia    *other causes include [[RhA]], [[AS]], spinal tumours, trauma, Paget's disease, scoliosis, spondylolisthesis, achondroplasia 
 +  *whole body fat-free mass and higher LSS risk (OR = 1.724)(([[https://www.nature.com/articles/s41467-026-70935-w|2026: Genetic architecture of lumbar spinal stenosis]]))
 +  *body mass index (BMI) and higher LSS risk (OR = 1.553)(([[https://www.nature.com/articles/s41467-026-70935-w|2026: Genetic architecture of lumbar spinal stenosis]]))
  
-====clinical features====+====Epidemiology==== 
 +  *affects over 100 million people globally, with an increasing incidence due to an ageing population 
 +  *prevalence of diagnostic LSS is around 11%, increasing significantly with age - the majority of radiological LSS cases are asymptomatic 
 +  *majority of diagnoses occurring between the ages of 50 and 70 
 + 
 +====Clinical features==== 
 +  *low back pain can be present or absent
   *pain on standing   *pain on standing
 +  *symptoms are typically relieved during sitting or forward flexion
   *neurogenic intermittent claudication may occur on prolonged standing, walking or extension of the lumbar spine   *neurogenic intermittent claudication may occur on prolonged standing, walking or extension of the lumbar spine
   *[[sciatica]] may occur and may be bilateral   *[[sciatica]] may occur and may be bilateral
   *severe cases may cause [[ces]]   *severe cases may cause [[ces]]
 +
 +====Diagnosis====
 +  *MRI or CT scan
 +
 +====Management====
 +  *analgesia
 +  *activity modification
 +  *physiotherapy
 +  *surgical Rx may be needed if:
 +    * symptoms do not improve and are a significant issue
 +    * [[ces]] develops
  
 =====Cervical spinal stenosis===== =====Cervical spinal stenosis=====
   *can be more dangerous than lumbar stenosis as it may cause [[n_spinalcordcomp]] and resulting myelopathy   *can be more dangerous than lumbar stenosis as it may cause [[n_spinalcordcomp]] and resulting myelopathy
  
spinal_stenosis.txt · Last modified: 2026/06/10 00:14 by gary1

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