Table of Contents
hypoaldosteronism
introduction
clinical features
aetiology
hypoaldosteronism
see also:
aldosterone
aldosterone antagonists (mineralocorticoid receptor antagonists (MRAs) )
type IV renal tubular acidosis
wikipedia
introduction
clinical features
hyperkalaemia
- often called
type IV renal tubular acidosis
even though
metabolic acidosis
is not a significant feature
urinary sodium wasting ⇒ volume depletion and hypotension
aetiology
hyporeninaemic hypoaldosteronism
loss of renal cell mass > 70% (most commonly diabetic nephropathy)
HIV / AIDS
ACE inhibitors
non-steroidal anti-inflammatory drugs (NSAIDs)
cyclosporine
aldosterone resistance
drugs -
aldosterone antagonists (mineralocorticoid receptor antagonists (MRAs) )
, trimethoprim, pentamidine
pseudohypoaldosteronism
primary aldosterone deficiency (rare)
primary adrenal insufficiency
congenital adrenal hyperplasia
aldosterone synthase deficiency