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acth

adrenocorticotropic hormone (ACTH)

introduction

  • ACTH (aka corticotropin) is a polypeptide hormone secreted by the anterior pituitary gland
  • its main actions are to increase synthesis and secretion of corticosteroids from the zona fasciculata of the adrenal cortex (via MC2R ACTH receptor) as part of the biological stress response
  • ACTH also has a role in bone physiology, especially in osteoblasts
  • half-life of ACTH in human blood is ~ 10 minutes
  • impaired secretion of ACTH is a cause of secondary adrenal insufficiency
  • excessive secretion of ACTH due to a pituitary tumour or ectopic production such as from small cell tumours of lung results in Cushing's syndrome
acth.txt · Last modified: 2014/05/11 21:48 (external edit)