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anca

antineutrophil cytoplasmic antibodies (ANCAs)

introduction

  • these antibodies characteristically occur in vasculitic syndromes
    • occur in more than 90% of patients with systemic Wegener's granulomatosis (with renal or pulmonary involvement, or both), 75% of patients with limited Wegener's granulomatosis (without renal involvement) and 50% of patients with microscopic polyarteritis.
    • c-ANCAs are actually antibodies to protein 3. The presence of c-ANCAs is 98% specific for these diseases;
  • changes in c-ANCA levels often precede disease activity and may guide treatment.
  • a primary care physician will rarely need to order this test
  • it helps in the diagnosis and management of only a very small number of patients with relatively rare conditions, and screening patients with nonspecific symptoms results in many false-positive p-ANCA results
anca.txt · Last modified: 2015/12/29 15:31 (external edit)