Adverse effects of benzodiazepine antagonists
may ppt withdrawal seizures → titrate dose & Rx 5mg IV midaz/diazepam;
may remove protective anticonvulsant effect of benzodiazepines in multiple OD;
re-sedation from overdose as duration of action is only 45-105min.
thus, in general, these are NOT used in the Mx of polypharmacy overdose, or in patients who may be dependent on benzodiazepines.
main use is to reverse acute excessive respiratory depressant effects of iatrogenic benzodiazepine excess.
benzodiazepine_antagonists.txt · Last modified: 2011/08/25 21:19 (external edit)