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bnp

B-type natriuretic peptide (BNP)

Introduction

  • B-type natriuretic peptide (BNP) is a cardiac-derived vasodilator and a biomarker for heart failure
  • elevated BNP and its cleavage product N-terminal proBNP (NT-proBNP) also predict adverse outcomes in acute coronary syndromes and other cardiovascular diseases1)

Potential pro-thrombotic activity

  • BNP can bind to natriuretic peptide receptor-A (NPRA) on platelets significantly increasing intracellular cGMP levels and enhanced platelet aggregation, granule secretion, spreading, and clot retraction in vitro2)
bnp.txt · Last modified: by gary1

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