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diverticulitis

diverticulitis

introduction

  • diverticula are herniations of the mucosa and submucosa or the entire wall thickness through the muscularis and in Western cultures, 95-95% involve the sigmoid colon, while in those living in Africa and Asia, prevalence is only 0.2% of the population and it mainly affects the right side!
  • adolescent cases are rare and generally associated with genetic disorders involving connective tissues in particular, such as:
  • Meckel's diverticulum is a rare congenital form but can present in adults
  • prevalence is increasing in the Western cultures and now are found in over 25% of patients undergoing colonoscopy, with prevalence increasing with age with prevalence being ~5% in those adults under 40 years, ~30% by age 60 years and 65% by age 85 years.
  • thought to be caused by low-fiber diet which is the highest risk factor for diverticular disease. The resultant low-bulk stool leads to increased segmentation of the colon during propulsion, causing increased intraluminal pressure and formation of diverticula.
  • affluent, mainly indoor societies in which passing flatus is regarded as being anti-social, may be an important contributor due to the gas pressures resulting from flatus retention and colonic contractions - perhaps it is better out than in!
  • risk increases with steroids and aging presumably due in part to impaired collagen maintenance.
  • complications of diverticular disease include:
      • 15% of those with diverticular disease will develop lower GIT bleeding - of these, 1/3rd will develop massive bleeding.
      • usually sudden onset of painless, bright red or wine colored stools and is often massive but usually stops spontaneously
    • perforation:
      • initial presentation may be as perforation and peritonitis
      • mortality following free perforation and generalised peritonitis exceeds 20%
    • diverticulitis +/- abscess formation +/- perforation +/- fistula formation
      • may result in altered bowel habit, lower abdominal pain, tenesmus, flatulence, distension, fevers, ureteric irritation,

initial Mx in ED

  • suspect in the older adult patient (particularly those with known diverticular disease) with LIF pain (LIF much more common than RIF) with no evidence of acute pyelonephritis, renal colic, abdominal aortic aneurysm (AAA) or gynaecologic cause
  • if rectal bleeding is the main presentation, then Mx as per lower GIT bleeding
  • nil orally or minimal ice chips to rest gut
  • iv fluids
  • bloods for FBE, U&E, consider CRP (and LFT's and lipase if R abdominal pain, consider blood cultures if temp > 38.5degC)
  • urinalysis
  • iv analgesia
  • consider anti-emetics if no evidence of bowel obstruction (see large bowel obstruction)
  • strict fluid balance chart
  • consider NGT if frequent vomiting
  • consider IDC if clinical dehydration, or impaired renal function
  • ECG if over 50 years age or risk of IHD
  • plain AXR is unlikely to be helpful unless one suspects other diagnoses such as bowel obstruction or sigmoid volvulus
  • contact surg team to decide on further Mx and possible CT abdomen
    • patients with known diverticular disease and mild symptoms may be considered for discharge on broad spectrum antibiotics without imaging
    • pelvic USS may be preferred over CT scan for women of child bearing age
    • CT abdomen with iv and oral contrast is now the gold standard for non-invasive diagnosis of diverticulitis
      • the two most common CT findings in uncomplicated diverticulitis are:
        • colonic wall thickening (wall thickness > 3 mm on the short axis of the lumen)
        • pericolic fat stranding
      • an identifiable inflamed diverticulum may also be visible
      • CT may fail to demonstrate early, mild cases of diverticulitis.
      • CT findings in complicated diverticulitis may include:
        • the presence of an abscess (defined as a fluid-containing mass with or without air and an enhancing wall)
        • contained or free extraluminal air bubbles or pockets
      • CT with rectal contrast is usually required to visualise fistulae, however, this is rarely performed

antibiotic Mx of diverticulitis

mild diverticulitis suitable for outpatient Mx

  • augmentin duo forte i bd for 5-7 days
  • if penicillin HS, then cephalexin 500mg qid plus metronidazole 400mg bd for 5-7 days

moderate diverticulitis warranting admission and iv Rx

  • iv ampicillin 1g 6h PLUS iv metronidazole 500mg 12h PLUS iv gentamicin 4-6mg/kg/day adjusted to age, creatinine clearance and gentamicin levels
    • if HS or C/I then contact infectious diseases team to decide on alternative Rx
    • continue iv for 5-7 days then change to oral regime once clinical condition is improving and tolerating oral fluids for at least 24 hours

severe diverticulitis

  • as for moderate but increase iv ampicillin dose to 2g per dose

abscess on CT scan

  • surg team to consider interventional radiology to drain it, or resort to bowel resection
diverticulitis.txt · Last modified: 2018/06/05 22:07 (external edit)