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frusemide

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frusemide / furosemide / Lasix

see also:

introduction

  • a potent potassium losing loop diuretic mainly used in the Rx of congestive cardiac failure
  • inhibits sodium and chloride absorption in the ascending limb of Henle's loop and in both the proximal and distal tubules

P/K

  • rapidly absorbed from GIT:
    • 60-69% in normal adults
    • onset of diuresis following oral administration is within 1 hour
    • peak effect occurs within the first or second hour
    • duration of diuretic effect is 6 to 8 hours
  • in intravenous usage:
    • onset of diuresis following oral administration is within 5 minutes
    • peak effect occurs within the first hour
    • duration of diuretic effect is ~2 hours

C/I

precautions

dose

  • usual starting dose is 20-40mg mane or 2mg/kg in children
  • may increase to 2nd dose at midday
  • may be carefully titrated up to 400 mg/day (except in advanced renal failure) in those patients with severe clinical oedematous states
  • patients with acute pulmonary oedema (APO) are often given 40mg slow iv stat dose and if no response within 1 hr, a 2nd 80mg slow iv dose given
frusemide.txt · Last modified: 2015/12/29 16:11 (external edit)