see also: acetylcholinesterase inhibitor poisoning - organophosphate insecticides, etc, toxicology, pharmacology main index

• DDT, methoxychlor, TDE

• BHC, lindane

• aldrin, chlordane, diedrin, heptachlor

• toxaphene (campheclor)

• Na channel blockade → rapid repetitive firing in most neurons
• Ca channel blockade
• ⇒ CNS stimulation → tremor, convulsions

• ⇒ carcinogenic in animals but not established in humans

• 'irreversible' acetylcholinesterase inhibitors
• see acetylcholinesterase inhibitor poisoning - organophosphate insecticides, etc

• 'irreversible' acetylcholinesterase inhibitors via carbamoylation of the esteratic site
• toxicity as for organophosphates but pralidoxime not usually advised as antidote
• see acetylcholinesterase inhibitor poisoning - organophosphate insecticides, etc

• nicotine alkaloid
  • rapidly absorbed mucosa & skin
  • ⇒ stimulates acetylcholine receptors:
    • sympathetic & parasympathetic ganglia
    • neuromuscular junctions → depolarising blockade
• rotenone
  • ⇒ GIT irritation if ingested
• pyrethrum
  • ⇒ if substantial ingestion/inhalation then risk of CNS excitation/convulsions & tetanic paralysis via Na channel mechanism similar to DDT
  • ⇒ contact dermatitis