ipratropium [OzEMedicine - Wiki for Australian Emergency Medicine Doctors]

ipratropium

Table of Contents

ipratropium
- introduction
- dose

ipratropium

see also:

introduction

a quaternary ammonium anticholinergic agent which is minimally absorbed (<1% of dose) when inhaled and thus has localised action to the respiratory system
use is mainly confined to asthma and chronic obstructive pulmonary disease (COPD)
paediatric doses via inhaler should ideally be delivered using a spacer.
muscarinic M3 receptor action half life 3hrs ⇒ duration action 4-6hrs, max. response at 1.5-2hrs ⇒ qid dosing

dose

moderate-severe paediatric asthma

< 6 years old: (Atrovent 20mcg/puff) 4 puffs then 2 puffs q6h
> 6 years old: (Atrovent 20mcg/puff) 8 puffs¹⁾ then 4 puffs q6h

severe-critical paediatric asthma

<20kg 250microg q20 mins x 3 via nebuliser then 2 puffs (40 microg) q6h
>20kg 500microg q20 mins x 3 via nebuliser then 4 puffs (80 microg) q6h²⁾

¹⁾

http://www.rch.org.au/clinicalguide/cpg.cfm?doc_id=5251

²⁾

http://www.nets.org.au/PDF/Acute%20Management%20of%20Infants%20and%20Children%20with%20Asthma%20.pdf

ipratropium.txt · Last modified: 2009/03/10 07:11 by 127.0.0.1