kisspeptin
kisspeptin
see also:
Introduction
- kisspeptin is an endogenous peptide hormone discovered in 1996 and receptors for it were discovered in 2000
- within the hypothalamus, kisspeptin is released from kisspeptin neurons and acts on nearby GnRH neurons to have a central role in regulation of LH secretion
- kisspeptin also acts peripherally, particularly on placenta, and on kidneys where it appears to have a role in aldosterone secretion
Roles of kisspeptin
- Kisspeptin neurons exist in close apposition with GnRH neurons in the hypothalamus
- Kisspeptin stimulates GnRH neurons (via Kisspeptin receptor - but may require oestradiol to work) leading to GnRH release and leads to an increase in circulating lutenizing hormone (LH) levels and appears to be a critical stimulus for the LH preovulatory surge
- Neurokinin B (NKB) has a role in steroid feedback control of GnRH release
- Dynorphin (DYN) is an endogenous opioid peptide, which acts primarily through the κ-opioid receptor and regulates progesterone-mediated negative feedback on GnRH release
- kisspeptin/neurokinin B/dynorphin [KNDy] neurons are co-located suggesting an integrated regulatory effect on GnRH release
- kisspeptin may also be the mediator for adipocyte-released leptin signalling and GnRH function
- kisspeptin may be the mediator in stress-induced suppression of reproductive function
- kisspeptin may be the mediator in prolactin-induced suppression of reproductive function
- kisspeptin may have a role in libido - trials of exogenous kisspeptin appear to increase libido in older men
- circulating levels of kisspeptin have been shown increase 7000-fold during pregnancy and appear to have a role in placental function with lower levels being found in placental dysfunction states such as gestational diabetes, hypertension, PE, etc, as well as being lower in women with recurrent miscarriages
kisspeptin.txt · Last modified: 2017/01/25 06:59 by 127.0.0.1