see also:

• antibiotics

• bactericidal, binds to 23S rRNA on the 50S subunit, activity enhanced at high pH
• active against most Gram +ves, Mycoplasma, Legionella, Chlamydia, Helicobacter
• uses for the usual macrolides (eg. erythromycin, roxithromycin):
  • atypical pneumonia, corynebacterial infections,
  • chlamydial infections esp. where tetracyclines C/I
  • Streptococcal infections where HS to penicillins
  • MAIS in AIDS pts
• eg. erythromycin, roxithromycin, clarithromycin, azithromycin