neuritin

Introduction

neuritin, also known as Cpg15, is a highly conserved neuropeptide identified in a 1993 screen for activity-regulated genes in the hippocampus dentate gyrus
it regulates synaptic plasticity, neurite growth, neuronal migration, and survival
it is involved in memory and learning
administration of neuritin in vivo promotes nerve regeneration
also expressed in adipose and placental tissue and in the lung and spleen to a lesser extent
it prevents the over-production of IgE and thus allergies, anaphylaxis, asthma and many auto-immune conditions could be the result of a deficiency of neuritin according to researchers at the Australian National University (ANU) in 2021 ¹⁾
- produced by BCL6-expressing Tregs, known as follicular regulatory T (Tfr) cells and is then taken up by B cells, causes phosphorylation of numerous proteins, and dampens IgE class switching - appears to be a central mechanism to suppress B cell-driven autoimmunity and IgE-mediated allergies
- reduced differentiation of mouse and human germinal centre B cells into plasma cells, downregulated BLIMP-1, and upregulated BCL6

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