odbaclofen
Table of Contents
baclofen overdose
see also:
introduction
- baclofen is a synthetic derivative of GABA and in Rx doses, mainly acts upon GABA-B receptors, inhibiting the release of the excitatory amino acids glutamate and aspartate
- in overdoses > 200mg in adults, this can result in significant CNS depression causing sedation and coma which may be profound and prolonged with hyporeflexia, hypotonia, fixed, dilated pupils, lasting 24-48hrs and thus admission to a ICU/HDU is generally needed
- it may also cause:
- resp. depression
- sinus bradycardia
- sinus tachycardia
- hypertension
- 1st degree heart block
- prolonged QTc (rare)
Mx of overdose
- most overdoses are minor and if asymptomatic or ingestion < 200mg in adults, can usually be discharged within 4hrs following ingestion
- in severe overdoses, Mx is supportive care
- following recovery from overdose one should recommence usual baclofen doses to prevent withdrawal syndrome (see below)
baclofen withdrawal syndrome
- may occur 24-48hrs after cessation of baclofen
- hallucinations
- visual disturbances
- seizures
- dyskinesia
odbaclofen.txt · Last modified: 2015/09/25 00:42 by 127.0.0.1