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schizophrenia

schizophrenia

introduction

  • The incidence and prevalence of schizophrenia show prominent variation between locations.
  • Males are more likely to develop schizophrenia than females (1.4 : 1)
  • Migrant status, urban birth or residence, and advanced paternal age are associated with an increased risk of developing schizophrenia.
  • genetic risk accounts for ~50% of the risk and includes:
    • C4 gene on chromosome 6 1)
  • Prenatal infection and malnutrition are associated with an increased risk of schizophrenia
  • Individuals with schizophrenia have a 2–3-fold increased mortality risk compared with the general population. This differential mortality gap may have worsened in recent decades.
  • the greater the exposure to cannabis, the greater the risk of developing schizophrenia.
  • in women, oestrogen “protects” women from developing severe schizophrenia at an early age.
  • fading oestrogen secretion at menopause in vulnerable women leads to relapse of schizophrenia symptoms or new, late-onset schizophrenia.

references and resources

schizophrenia.txt · Last modified: 2016/01/28 23:26 by gary1