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  • a human parasitic disease caused by the nematode (roundworm) Strongyloides stercoralis, or sometimes S. fülleborni.
  • thought to affect 30–100 million people worldwide, mainly in tropical and subtropical countries.
  • does not require an intermediate host but does require maturation in soil

clinical pictures

respiratory infection and Löffler's syndrome

  • Loffler's syndrome (acute onset eosinophilic pneumonitis) can also be caused by Ascaris lumbricoides, and the hookworms Ancylostoma duodenale and Necator americanus.

chronic with mainly digestive symptoms

  • may become asymptomatic
  • abdominal pain, diarrhoea, eosinophilia, urticarial rashes (esp. waist and buttocks)

reinfection with larva migration

  • there may be respiratory, skin and digestive symptoms

hyperinfection in the immunocompromised

  • may involve many organ systems including CNS
  • may occur many decades after initial infection and develops when immunity falls eg. high dose corticosteroids, organ transplant drugs, malnutrition, advanced tuberculosis (TB), etc.


uncomplicated disease

  • The drug of choice for the treatment of uncomplicated strongyloidiasis is ivermectin.
  • ivermectin does not kill the strongyloides larvae only the adult worms therefore repeat dosaging may be necessary to properly eradicate the infection.
  • There is an auto-infective cycle of roughly two weeks in which ivermectin should be re-administered however additional dosaging may still be necessary as it will not kill strongyloides in the blood or larvae deep within the bowels or diverticuli.
strongyloidiasis.txt · Last modified: 2020/04/04 08:36 by gary1

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