Table of Contents
- a human parasitic disease caused by the nematode (roundworm) Strongyloides stercoralis, or sometimes S. fülleborni.
- thought to affect 30–100 million people worldwide, mainly in tropical and subtropical countries.
- does not require an intermediate host but does require maturation in soil
- often asymptomatic
- usually associated with eosinophilia
respiratory infection and Löffler's syndrome
- Loffler's syndrome (acute onset eosinophilic pneumonitis) can also be caused by Ascaris lumbricoides, and the hookworms Ancylostoma duodenale and Necator americanus.
chronic with mainly digestive symptoms
- may become asymptomatic
- abdominal pain, diarrhoea, eosinophilia, urticarial rashes (esp. waist and buttocks)
reinfection with larva migration
- there may be respiratory, skin and digestive symptoms
hyperinfection in the immunocompromised
- may involve many organ systems including CNS
- may occur many decades after initial infection and develops when immunity falls eg. high dose corticosteroids, organ transplant drugs, malnutrition, advanced tuberculosis (TB), etc.
- The drug of choice for the treatment of uncomplicated strongyloidiasis is ivermectin.
- ivermectin does not kill the strongyloides larvae only the adult worms therefore repeat dosaging may be necessary to properly eradicate the infection.
- There is an auto-infective cycle of roughly two weeks in which ivermectin should be re-administered however additional dosaging may still be necessary as it will not kill strongyloides in the blood or larvae deep within the bowels or diverticuli.
strongyloidiasis.txt · Last modified: 2020/04/04 08:36 by gary1