see also:

• argipressin (vasopressin / ADH)

• vasopressin-V2 receptor antagonists have been used to Rx:
  • dilutional hyponatraemia
  • volume overload in congestive cardiac failure
  • reducing rate of progression of ADPKD

• appears to substantially reduce disease progression in patients with ADPKD however almost 25% of patients discontinued Rx due to adverse effects such as aquaresis (excretion of electrolyte-free water) and hepatic adverse events
• see NEJM 367;25. Dec 20th, 2012. pp2407-2418