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avoid prolonged courses, particularly in the elderly as risk of cholestatic jaundice, consider dicloxacillin instead as risk is half that for flucloxacillin


  • flucloxacillin is a narrow spectrum penicillin active against Gram +ves including St. aureus
  • not active against Gram negative bacilli, methicillin resistant Staphylococcus, nor Streptococcus faecalis.
  • category B1 in pregnancy
  • is excreted in breast milk in trace amounts. An alternative feeding method is recommended to avoid any possible sensitisation of the newborn.


adverse reactions

  • HS reaction including anaphylaxis
  • cholestatic jaundice - usually after several weeks of Rx
  • reduces binding of bilirubin to albumin thus avoid in jaundiced neonates or premature neonates
  • sodium load in renally impaired patients - each 1g flucloxacillin contains 2mmol sodium


oral dose

  • adults 500mg qid
  • children 2-10 years 250mg qid
  • children < 2yrs: 125mg qid

iv dose

  • adult dose 500mg - 1g 6hrly
  • children 2-10 years 250-500mg qid
  • children < 2yrs: 125-250mg qid
flucloxacillin.txt · Last modified: 2012/01/09 03:59 by

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