Historical perspective of calcium channel physiology and pharmacology


  • It was reported in 1960 that verapamil, a putative coronary vasodilator, possessed -ve inotropic & chronotropic effects not seen with nitrate vasodilators.
    • in 1967 it was suggested that this was due to decreased movement of Ca into cardiac myocytes;
  • In 1969, it was shown there are 2 inwardly directed ionic currents that mediated atrial depolarisation:
    • fast Na channel (blocked by tetrodotoxin) & slow Ca channel;
  • In 1972, gallopamil, a verapamil derivative, was shown to block the slow Ca channel;
h_calciumchannel.txt · Last modified: 2008/09/15 00:55 by

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