Historical perspective of calcium channel physiology and pharmacology
- It was reported in 1960 that verapamil, a putative coronary vasodilator, possessed -ve inotropic & chronotropic effects not seen with nitrate vasodilators.
- in 1967 it was suggested that this was due to decreased movement of Ca into cardiac myocytes;
- In 1969, it was shown there are 2 inwardly directed ionic currents that mediated atrial depolarisation:
- fast Na channel (blocked by tetrodotoxin) & slow Ca channel;
- In 1972, gallopamil, a verapamil derivative, was shown to block the slow Ca channel;
h_calciumchannel.txt · Last modified: 2008/09/15 00:55 by 127.0.0.1