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odphenothiazines

Phenothiazine overdose

Phenothiazine overdose:

  • Thioridazine & mesoridazine are the only anti-psychotics associated with single-drug fatal overdoses as these have quinidine-like actions & thus can induce ventricular arrhythmias, management of these should be as for tricyclic antidepressants. Other anti-psychotics are rarely fatal on OD.

Symptoms of overdose with other antipsychotics include:

  • drowsiness, agitation, coma 
  • NM excitability which may lead to convulsions (may be Mx with diazepam or phenytoin
  • miotic pupils, decreased deep tendon reflexes 
  • hypotension:
  • hypothermia (though fever may occur later)
  • delayed gastric emptying (hence gastric lavage may be useful even hrs after ingestion) 
odphenothiazines.txt · Last modified: 2008/09/22 15:10 (external edit)