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prochlorperazine (Stemetil)


adverse effects


  • PH adverse reactions to phenothiazines such as hepatic effects, blood dyscrasias
  • bone marrow depression
  • hypotension
  • CNS depression (eg. drug overdose)


  • avoid in those with PH extrapyramidal reactions
  • elderly - falls risk, delirium risk
  • renal impairment
  • Parkinson's disease
  • phaechromocytoma
  • myasthenia gravis
  • prostatism
  • hepatic impairment
  • epilepsy or seizure risk (eg. brain tumour)
  • risk of prolonged QTc - bradycardia, hypokalaemia, other drugs that prolong QTc, etc
  • hypoparathyroidism with hypocalcaemia increases risk of dystonic reactions
  • high dose or prolonged use - risk of irreversible tardive dyskinesia
  • pregnancy, labour, lactation
  • children < 2yrs old
  • suspected Reye's syndrome
  • diabetes
  • hypothermia risk (eg. swimming in cold water)
  • hyperthermia risk (eg. hot weather)
  • thromboembolism risk eg. PH stroke
  • use with other sedatives
  • use with pro-convulsants (eg steroids)
  • interactions with anticonvulsants, warfarin, other medications

adult dosage

  • usual oral dose: 5-10mg orally 2-4 times a day (adults can be given an initial 20mg dose orally and if necessary a further 10mg oral dose 2 hours later according to PMI)
  • usual rectal dose: 25mg suppository can be followed by oral dose 6 hours later
  • usual im dose: 12.5mg deep im injection can be followed by oral dose 6 hours later
  • slow iv dose: 2.5-10mg can be given by slow iv injection or infusion with saline (max. adult rate 5mg/minute1)).
prochlorperazine.txt · Last modified: 2019/06/27 07:35 by

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