vitamin K

Introduction

vitamin K is an essential vitamin involved in various functions:
- production of coagulation factors by the liver
- bone health:
  - vitamin K signaling appears to mainly act through bone-forming cells as γ-glutamyl carboxylase and vitamin K oxidoreductase are expressed predominantly in osteoblasts rather than osteoclasts
  - growth arrest-specific 6 (GAS6), a signaling molecule secreted by osteoblasts, activates the TAM family receptors, AXL and MerTK on pre-osteoclasts, GAS6 strongly promotes osteoclast formation and increases the number of nuclei per osteoclast, producing larger multinucleated cells capable of enhanced bone resorption ¹⁾

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