it seems that higher vitamin B6 levels (eg >=100mg/day supplements), may lead to the development of a predominantly, if not exclusively, sensory neuropathy of the axonal type however, data is inclonclusive due to small sample sizes. Some advisory bodies are recommending max daily intake of 50mg/day - average dietary intake is 5mg/day
1) However TGA Australia anecdotal reports of a number of patients developing issues with under 50mg/d
2) It appears the mechanism of pyridoxine induced peripheral neuropathy is necrosis of the dorsal root ganglion and is duration and dose dependent.
3)