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kambo

Kambo poisoning

see also:

Introduction

  • Kambo is a purging ritual using topically applied poison scraped from the back of the Amazonian giant tree frog (Phyllomedusa bicolor, kambô or sapo) that induces severe vomiting and exponents use it to “rid the body of toxins, and can resolve emotions to understand them, cure depression, drug dependency, heart problems, high blood pressure and gastrointestinal issues”
  • Kambo devotees make small dot-like burns on their skin before applying the poison
  • at first, the person feels a few moments of serenity, but within seconds, that feeling turns to suffering and can force the person to vomit
  • the effect shortly fades away
  • outside of South America, it first became known as an alternative therapy in the late 2010s
  • occasionally this practice may be fatal:
    • within minutes in the case of a woman in Mullumbimby in March 2019
    • within 12 hours or so in the case of a 46yr old man who died from a perforated oesophagus in Oct 2021 at the six-day Dreaming Arts Festival held in Collins Creek, north of Kyogle 1)
  • in 2021 the Therapeutic Goods Administration of Australia (TGA) banned the use of Kambo in Australia and classified it as a schedule 10 poison.

Pharmacology of the toxin

  • contains various peptides:
    • dermorphin
      • an opioid hepta-peptide which binds as an agonist with high potency and selectivity to mu opioid receptors with a potency 30-40x that of morphine
    • deltorphin
      • an exogenous opioid heptapeptide which is a very potent and highly specific agonist of the δ-opioid receptor
      • have an unusually high blood–brain barrier penetration rate
      • the nonselective opiate antagonist naloxone (Narcan) inhibits deltorphin uptake by brain microvessels
    • sauvagine
      • neuropeptide from the corticotropin-releasing factor (CRF) family of peptides
      • interacts with corticotropin releasing factor receptors 1 and 2
      • exerts similar physiological effects as corticotropin-releasing hormone
    • dermaseptins
      • the first vertebrate peptides demonstrated as having a lethal effect on the filamentous fungi implicated in severe opportunistic infections accompanying immunodeficiency syndrome and immunosuppressive drug therapy
      • has membrane-lytic activity
    • phyllomedusin
    • phyllokinin
    • caerulein
    • adrenoregulin

Usual acute effects

  • tachycardia
  • nausea
  • vomiting
  • diarrhoea

Potential serious adverse effects

kambo.txt · Last modified: 2023/05/09 10:19 by gary1

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