Table of Contents
- serum lipase levels are used primarily as an indicator for acute pancreatitis when it starts to rise 3-6hrs after onset and usually peaks around 24hrs from onset, but as there is significant reabsorption from the renal tubules, levels remain elevated for 8-14 days.
- has a greater sensitivity than amylase for alcoholic pancreatitis (sens. > 85%), and has higher specificity, although this depends upon what cut-off value is used - most use 2-3x normal upper limit.
- there are various types of lipase enzymes including pancreatic, hepatic, intestinal, lingual and lipoprotein.
causes of raised serum lipase
levels > 3x upper limit of normal
- acute pancreatitis - >90% of cases of such high levels are due to acute pancreatitis of which there are many possible causes, although most commonly are biliary or alcoholic
levels < 3x upper limit of normal
- mild, early or resolving acute pancreatitis
- chronic pancreatitis
- pancreatic calculus
- bowel infarction
- renal failure
- non-pancreatic abdominal pain (~10% have raised lipase)
- macrolipasaemia (lipase bound to macromolecules - mainly immunoglobulins)
- IgG-bound lipase in a patient with a non-Hodgkin lymphoma
- macrolipasemia and macroamylasemia in association with poly-IgA
- IgG- and an IgA-bound macrolipase
- α2-MG-bound macrolipase
- cystic fibrosis
lipase.txt · Last modified: 2015/10/04 12:57 by 127.0.0.1