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siadh

syndrome of inappropriate ADH secretion (SIADH)

introduction

  • SIADH is increased ADH secretion despite normal or elevated plasma volume which causes reduced renal water excretion and resulting hyponatraemia and hypo-osmolality

Diagnostic criteria

  • Barrter and Schwartz:
    • decreased serum osmolality (<275 mOsm/kg)
    • increased urine osmolality (>100 mOsm/kg)
    • euvolaemia
    • increased urine sodium (>20 mmol/L)
    • no other cause for hyponatraemia

aetiology

central nervous system causes

drug-induced

increased secretion of ADH

increased effects of ADH

other drugs include

pulmonary causes

  • most pulmonary conditions can cause it

paraneoplastic

ectopic ADH secretion

other causes

  • exercise-induced hyponatraemia
  • giant cell arteritis
  • idiopathic

Mx

siadh.txt · Last modified: 2021/06/20 16:53 by gary1