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hcv

hepatitis C virus

introduction

hepatocellular carcinoma

  • HCV infection confers a 15-20x risk of hepatocellular carcinoma (but most of this risk is limited to those with advanced hepatic fibrosis or cirrhosis)
    • HCV epidemics: Japan 1920's; southern Europe 1940's; Nth America 1960's-70's;
    • in patients with hepatocellular carcinoma, HCV markers are found in 80-90% if Japanese, 44-66% if Italian, 30-50% if USA.
    • risk factors of hepatocellular carcinoma with HCV infection include:
      • older age at time of infection
      • males
      • coinfection with HIV or HBV
      • possibly diabetes or obesity
      • chronic heavy alcohol intake
hcv.txt · Last modified: 2011/10/04 08:08 by gary