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immunosuppressants

immunosuppressants

classes of immunosuppressant medications

  • topical immune modifiers:
    • imiquimod - Rx of solar keratoses, BCC, etc
  • selective interleukin inhibitors:
    • canakinumab - IL-1beta inhibitor for Rx of cryopyrin associated periodic syndromes
    • tocilizumab - IL-6 inhibitor for Rx of rheumatoid arthritis
    • ustekinumab - IL-12 and IL-23 monoclonal Ab for Rx of severe psoriasis
  • selective tumour necrosis factor (TNF) inhibitors:
  • interferons:
    • interferon alpha-2b: Rx of hairy cell leukaemia, Kaposi's sarcoma, chronic hepatitis B/C, CML, multiple myeloma, non-Hodgkin's lymphoma, melanoma, etc
    • interferon beta-1a: Rx of relapsing multiple sclerosis (MS)
    • interferon beta-1b: Rx of multiple sclerosis (MS)
    • interferon gamma-1b: reduces infections in chronic granulomatous disease
  • other transplant rejection prevention agents:
    • mycophenolate mofetil - renal allograft rejection in children
    • everolimus - mTOR inhibitor also used to Rx AD polycystic kidney disease (ADPKD)
    • sirolimus
    • tacrolimus - macrolide lactone immunosuppressant used as adjunctive Rx
    • antithymocyte globulin - to reduce peripheral T cell function in renal transplant recipients
    • basiliximab - renal allografts
  • other immunosuppressant agents used in Rx of rheumatoid arthritis:
    • leflunomide - Rx of rheumatoid arthritis and psoriatic arthritis
    • abatacept - CD80+CD86 and CD28 interaction costimulator modulator.
  • other immunosuppressant agents used in Rx of multiple sclerosis (MS)
    • glatiramer
    • cladribine - purine nucleoside analogue
    • natalizumab - humanised IgG-4 monoclonal Ab to alpha-4 integrin
  • immunosuppressant agents used to Rx hereditary angioedema (HAE):
    • icatibant - bradykinin 2 receptor antagonist
    • human C1 esterase inhibitor
  • immune modulators for Rx of asthma:
    • omalizumab - anti-IgE agent which appears to reduce seasonal peaks in exacerbations in inner city children with asthma 1)
  • lenalidomide - for Rx of multiple myeloma and transfusion dependent anaemia
  • thalidomide - for Rx of multiple myeloma
  • temsirolimus - Rx of advanced renal cell Ca, and relapsed, refractory mantle cell lymphoma
1)
NEJM 2011 364:11
immunosuppressants.txt · Last modified: 2020/04/02 12:37 by gary1