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immunocompromised

the immunocompromised patient in the ED

Introduction

Examples of high risk immunocompromised patients

  • Haematologic neoplasms: leukemias, lymphomas, myelodysplastic syndromes
  • Post-transplant: solid organ (on immunosuppressive therapy), haematopoietic stem cell transplant (within 24 months or on treatment for GVHD)
  • Immunocompromised due to primary or acquired immunodeficiency (including HIV infection)
  • Current chemotherapy (within past 2 weeks) or radiotherapy
  • High-dose corticosteroids (≥20 mg of prednisone per day, or equivalent) for ≥14 days
  • All biologics and most disease-modifying anti-rheumatic drugs (DMARDs) as defined as follows:
    • Azathioprine >3.0 mg/kg/day
    • 6-Mercaptopurine >1.5 mg/kg/day
    • Methotrexate >0.4 mg/kg/week
    • Prednisone >20 mg/day. If <14 days treatment, until treatment ceased
    • Tacrolimus (any dose)
    • Cyclosporine (any dose)
    • Cyclophosphamide (any dose)
    • Mycophenolate (any dose)
    • Combination (multiple) DMARDs irrespective of dose
immunocompromised.txt · Last modified: 2020/04/02 12:39 by gary1