serum lipase levels are used primarily as an indicator for acute pancreatitis
when it starts to rise 3-6hrs after onset and usually peaks around 24hrs from onset, but as there is significant reabsorption from the renal tubules, levels remain elevated for 8-14 days.
has a greater sensitivity than amylase
for alcoholic pancreatitis (sens. > 85%), and has higher specificity, although this depends upon what cut-off value is used - most use 2-3x normal upper limit.
there are various types of lipase enzymes including pancreatic, hepatic, intestinal, lingual and lipoprotein.
causes of raised serum lipase
levels > 3x upper limit of normal
- >90% of cases of such high levels are due to acute pancreatitis of which there are many possible causes, although most commonly are biliary or alcoholic
levels < 3x upper limit of normal
lipase.txt · Last modified: 2015/10/04 23:57 (external edit)