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cmv

cytomegalovirus (CMV)

introduction

  • CMV is a member of the Herpesviridae family
  • ~60% of western populations have been infected with CMV, most are asymptomatic, but it may become reactivated if T-cell immunity falls
  • appears to be the cause of glioblastoma multiforme 1)
    • CMV proteins are highly expressed in over 90% of GBM tumors

primary CMV infection

  • if symptomatic, incubation period is 9-60 days
  • may cause:

CMV infection in the immunocompromised

CMV reactivation

  • CMV normally remains dormant but may become reactivated if T-lymphocyte mediated immunity becomes compromised as in:
  • CMV viraemia may then lead to:
    • severe pneumonitis
    • secondary haemophagocytic syndrome
  • if CMV reactivation occurs during breastfeeding:
    • the ensuing immune response may affect milk composition, neonatal gut flora with lower levels of beneficial flora, and impaired development of gut microbiome and impaired infant growth. 2)
cmv.txt · Last modified: 2024/07/29 03:13 by gary1

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