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renal medicine (nephrology)

drug-induced renal disease


  • many drugs implicated
  • dose-related direct nephrotoxicity:
    • amphotericin B, gentamicin
  • hypersensitivity
    • penicillins, sulphonamides
  • obstructive uropathy due to crystal formation
    • sulphonamides
  • osmotic nephrosis
    • low Mw dextran
  • tetracyclines
    • 2 mechanisms:
      • renal failure
      • Fanconi syndrome

drug-induced LE

nephrotic syndrome

papillary necrosis

  • analgesic abuse

retro-peritoneal fibrosis

  • methysergide, ergotamine, methyldopa

metabolic effects


  • renal pelvis mesothelial tumour eg. analgesics

aetiology of small kidneys

  • chronic glomerulonephritis (GN) - regular outline
  • chronic acute pyelonephritis - irregular outline
  • other chronic nephropathy eg. interstitial nephritis
  • renal artery stenosis
  • atrophy following chronic obstruction
  • congenital renal hypoplasia

aetiology of large kidneys

renal.txt · Last modified: 2013/01/21 15:24 by

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